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Index > Protein center > Gpc1(Gene name) > Mouse
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  • Gpc1 (Gene name),
  • Glypican-1 (Protein name ),  GPC1_MOUSE from NCBI database.
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  • General Annotation
  • |
  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    Gpc1;
    Protein name:
    Glypican-1;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Cell surface proteoglycan that bears heparan sulfate. May play an important role in the trophic and injury responses of neurons.
    Subcellular Location:
    Secreted glypican-1 Secreted extracellular space
    Protein Attributes:
    Sequence length:
    557
    Sequence:
    50:
    MELRTRGWWL | LCAAAALVVC | ARGDPASKSR | SCSEVRQIYG | AKGFSLSDVP | 
    100:
    QAEISGEHLR | ICPQGYTCCT | SEMEENLANH | SRMELESALH | DSSRALQATL | 
    150:
    ATQLHGIDDH | FQRLLNDSER | TLQEAFPGAF | GDLYTQNTRA | FRDLYAELRL | 
    200:
    YYRGANLHLE | ETLAEFWARL | LERLFKQLHP | QLLPDDYLDC | LGKQAEALRP | 
    250:
    FGDAPRELRL | RATRAFVAAR | SFVQGLGVAS | DVVRKVAQVP | LAPECSRAIM | 
    300:
    KLVYCAHCRG | VPGARPCPDY | CRNVLKGCLA | NQADLDAEWR | NLLDSMVLIT | 
    350:
    DKFWGPSGAE | SVIGGVHVWL | AEAINALQDN | KDTLTAKVIQ | ACGNPKVNPH | 
    400:
    GSGPEEKRRR | GKLALQEKPS | TGTLEKLVSE | AKAQLRDIQD | FWISLPGTLC | 
    450:
    SEKMAMSPAS | DDRCWNGISK | GRYLPEVMGD | GLANQINNPE | VEVDITKPDM | 
    500:
    TIRQQIMQLK | IMTNRLRGAY | GGNDVDFQDA | SDDGSGSGSG | GGCPDDTCGR | 
    550:
    RVSKKSSSSR | TPLTHALPGL | SEQEGQKTSA | ATCPEPHSFF | LLFLVTLVLA | 
    557:
    AARPRWR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Glypican-1
    Cat.:
    E9038h
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    Packing:
    96T
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    ELISA Kit for Mouse Glypican-1
    MSDS:
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    ELISA Kit for Mouse Glypican-1
    Cat.:
    E9038m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Glypican-1
    Cat.:
    E9038r
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    MSDS:
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    96T
    ELISA Kit for Mouse Glypican-1
    Cat.:
    E9038b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Glypican-1
    Cat.:
    U9038r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Glypican-1
    Cat.:
    U9038b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Glypican-1
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Glypican-1
    Cat.:
    U9038m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Glypican-1
    Cat.:
    U9038h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Glypican-1
    Polyclonal Antibody for Mouse Glypican-1
    Cat.:
    P9038Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Glypican-1
    Polyclonal Antibody for Mouse Glypican-1
    Polyclonal Antibody for Mouse Glypican-1
    Cat.:
    P9038Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Glypican-1
    Monoclonal Antibody for Mouse Glypican-1
    Monoclonal Antibody for Mouse Glypican-1
    Monoclonal Antibody for Mouse Glypican-1
    Monoclonal Antibody for Mouse Glypican-1
    Protein for Mouse Glypican-1
    Protein for Mouse Glypican-1
    Protein for Mouse Glypican-1
    Protein for Mouse Glypican-1
    Protein for Mouse Glypican-1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    3. 3.
      "Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate."
      Mani K. , Cheng F. , Havsmark B. , Jonsson M. , Belting M. , Fransson L.A.
      J. Biol. Chem.278:38956-38965(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COPPER-BINDING;SUBCELLULAR LOCATION;GLYCOSYLATION
    4. 4.
      "The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-nitric oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo."
      Cappai R. , Cheng F. , Ciccotosto G.D. , Needham B.E. , Masters C.L. , Multhaup G. , Fransson L.A. , Mani K.
      J. Biol. Chem.280:13913-13920(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;COPPER-BINDING;ZINC-BINDING;S-NITROSYLATION;GLYCOSYLATION
    5. 5.
      "Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes."
      Mani K. , Cheng F. , Fransson L.A.
      Glycobiology16:1251-1261(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;GLYCOSYLATION
    6. 6.
      "Copper-dependent co-internalization of the prion protein and glypican-1."
      Cheng F. , Lindqvist J. , Haigh C.L. , Brown D.R. , Mani K.
      J. Neurochem.98:1445-1457(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    7. 7.
      "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
      Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    8. 8.
      "Involvement of glypican-1 autoprocessing in scrapie infection."
      Lofgren K. , Cheng F. , Fransson L.A. , Bedecs K. , Mani K.
      Eur. J. Neurosci.28:964-972(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;ASSOCIATION WITH PRPN AND AN ANIMAL MODEL OF SCRAPIE DISEASE
    9. 9.
      "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L. , Raginski K. , Tarasova Y. , Tchernyshyov I. , Bausch-Fluck D. , Elliott S.T. , Boheler K.R. , Van Eyk J.E. , Wollscheid B.
      Mol. Cell. Proteomics8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-79 AND ASN-116
      tissue: Myoblast.
    10. 10.
      "Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis."
      Jen Y.H. , Musacchio M. , Lander A.D.
      Neural Dev.4:33-33(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
    11. 11.
      "Glypican-1 mediates both prion protein lipid raft association and disease isoform formation."
      Taylor D.R. , Whitehouse I.J. , Hooper N.M.
      PLoS Pathog.5:E1000666-E1000666(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;ASSOCIATION WITH A MOUSE MODEL OF SCRAPIE DISEASE
    12. 12.
      "A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation."
      Gutierrez J. , Brandan E.
      Mol. Cell. Biol.30:1634-1649(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    13. 13.
      "A Kras(G12D)-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesis."
      Whipple C.A. , Young A.L. , Korc M.
      Oncogene31:2535-2544(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH PANCREATIC DUCTAL ADENOCARCINOMAS;DISRUPTION PHENOTYPE;FUNCTION
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